Lawrence Sabir had nine points and four assists in his second game back from injury, but he wasn't enough to stop the host Eagles from shooting lights out in the second half.
Despite 15 points from Nolan Hagerty, the Judges couldn't overcome 60 percent shooting from the Yellowjackets, including 67 percent in the second half.
Junior Chandler Jones had 17 points and 14 rebounds, including 11 and 9 in the second half, as the Judges overcame a seven-point halftime deficit to reclaim a share of the UAA lead.
Five players scored in double figures, including a career-high 14 from Dylan Lien, as the Judges improve to 14-4 and moved into a three-way tie for the conference lead.
The Judges are nationally ranked for the first time since 2013, were featured on the Sportscenter Top 10, and earned national Team and Coach of the Week honors.
The Judges shot 54 percent from the field and 50 percent from 3-point range in their largest-ever win over Rochester in the 66th meeting between the teams. Nolan Hagerty had a career-high 18 points, five assists and four rebounds.
The Judges hit 10 first-half 3-pointers as they built a 19-point lead then held off the Violets to improve to 9-3, 1-0 UAA. Collin Sawyer led with 19 points, 15 in the first half.
Dylan Lien hit a key 3-pointer down the stretch to make it a two-possession game as Brandeis erased a nine-point halftime deficit. The Judges are off to their best start since 2013-14.
Chandler Jones scored 16 points and had two key offensive rebounds, while Nolan Hagerty posted his second double-double with 10 points and 10 rebounds.
The men's basketball program becomes the eighth different Brandeis program over the past decade to partner with Team IMPACT to help improve the lives of youngsters with life-threatening illnesses.
Chandler Jones scored a career-high 26 points and dished a career-best seven assists as the Judges outscored the Vikings, 63-36, in the second half. Brandeis missed just 10 shots in the stanza.
Junior Chandler Jones scored 25 points for the second time this season, including 21 in the second half, but the Jumbos scored the game's final 10 points to pull out the win.