The Judges led 20-2 with just over six minutes gone in the game, but were unable to keep their hot shooting up. Hannah Nicholson did her part with 14 points and 11 rebounds.
Despite 16 points from Hannah Nicholson and another near triple-double from Camila Casanueva, who had 14 points, 10 boards and seven assists, the Judges split the season series with the Yellowjackets for the sixth time in eight seasons.
Junior transfer guard Courtney Thrun notched career-highs with 17 points and 12 rebounds as the Judges clinched their first winning record since 2014-15.
Courtney Thrun had a career-high 16 points off the bench, while Camila Casanueva (13p, 10a) and Hannah Nicholson (11p, 14r) each recorded double-doubles, but it wasn't enough against the Spartans.
Francesca Marchese had 4 3-pointers on her birthday as the Judges finished their best non-league slate since 2008-09, when they reached the Elite Eight of the NCAA tournament.
The Brandeis women scored the game's first 13 points and never looked back. Hannah Nicholson led the way with her fourth double-double of the season with 14 points and 12 rebounds.
Camila Casanueva registered her sixth career 20-point game, while Hannah Nicholson had her seventh career double-double with 14 points and 12 rebounds.
Hannah Nicholson had 19 points - including a jumper in OT that put the Judges ahead for good - and grabbed a career-high-tying 16 rebounds. Brandeis' 99 points were the second-highest total in program history.
After averaging 22.5 points and 5.5 assists per game and setting new personal bests in both categories, Camila Casanueva was honored for the second time in her career.
The Judges posted their biggest win since the start of the 2015 season thanks to 14 points and nine rebounds from Hannah Nicholson and 13 points and seven assists from rookie Emma Reavis.
Brandeis outscored Roger Williams, 25-11, in the second quarter, as four players scored in double figures, including Hannah Nicholson's double-double of 13 points and 15 rebounds.